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Comparative efficacy and safety of semaglutide 2.4 mg and tirzepatide 5–15 mg in obesity with or without type 2 diabetes: A systematic review of Phase 3 clinical trials
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Semaglutide targets GLP-1 only. Tirzepatide targets GLP-1 AND GIP. The results: → 22.5% average weight loss (vs 15% for semaglutide) → Superior insulin sensitivity improvement → Better preservation of lean mass during
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