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In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with
27.94
GLP-1 Drugs and Type 1 Diabetes: Less Insulin, Better Time in Range — What the Evidence
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Virta Health announces first-of-its-kind peer-reviewed study proving its approach is an effective off-ramp from GLP-1s for sustained weight loss
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Full article: GLP-1 receptor agonists in the treatment of type 2 diabetes: role and clinical experience to date
20.62
A Big Week for GLP-1 Drugs - by Eric Topol
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Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression
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Trial Scorecard: ACHIEVE-1
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