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Oral GLP-1-Based Therapeutics in the Obesity–Metabolic Syndrome–Diabetes Continuum: Translational Advances, Clinical Barriers, and Emerging Strategies
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In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with
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Full article: GLP-1 receptor agonists in the treatment of type 2 diabetes: role and clinical experience to date
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Potential oral small-molecule GLP-1R agonist. | DDDT
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Anesthetic Considerations for Patients Taking Glucagon-Like Peptide-1 Agonists
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First Time: Orally Available GLP-1 Agonist More Effective than DPP-IV Inhibitor | DZD
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In the ATTAIN-1 phase 3, randomized trial, the use of orforglipron, an oral glucagon-like peptide-1 receptor agonist, led to significant mean body-weight reductions in patients with obesity, as compared with placebo. Full
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