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Friday, May 29
Not an April fool's prank! The small molecule GLP 1 receptor agonist, orforglipron, has been approved by the FDA under the trade name, "Foundayo." We discussed the data in a fall 2025 episode Mechanisms of GLP 1 Receptor Agonist Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation The American Journal of Medicine Frontiers GLP 1 Receptor Agonists: Beyond Their Pancreatic Effects Table 1 from Cardiovascular Effects of Glucagon Like Peptide 1 Receptor Agonists Semantic Scholar GLP 1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal. First Generic of Once Daily GLP 1 Injection Approved for Diabetes MedPage Today
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Runs small
Size: 4 Big Kid, Color: Pearl Yellow
I wish they went past size 4 but cute nonetheless.
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Reviewed in the United States on August 29, 2024
★★★★★ 5
Compra excelente
Excelente y buen precio
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Reviewed in the United States on November 14, 2024
★★★★★ 5
The best shoe brand I have found for toddlers! Exceptional quality
Size: 12 Little Kid, Color: Black/Beige
I have ordered a handful of shoes from Mini Melissa in the past, so I knew to size up. I typically order 1 to 3 sizes larger than what my daughter currently wears depending on the season and type of shoe. For this shoe, I ordered about 3 sizes up, so that she will be able to wear them next spring / summer and I am glad I did. They are a little large on her now, but I know we will get a lot of use out of them next summer playing in the yard, pool and beach! As with all Mini Melissa shoes, the first thing I do when I open the box is smell them - their shoes have the most pleasant scent! They make the best jelly-like quality shoes; they are absolutely worth the price for the quality and style you receive. They hold up very well - they are the only shoes that she outgrows before the shoe breaks down or looks unwearable. My daughter has worn many of their styles, and has never gotten a blister or complained about the comfort. They are supportive, but flexible and even as young as she is, she gets so excited for cute shoes! I ordered the beige and black for something neutral we can wear with many different outfits and that won't show dirt on the sole. The color is exactly as pictured. I really appreciate that top straps are functional and adjustable. She has a bit of a wider foot, so this allows us to get even more use out of them. I am very glad I ordered these and will continue to tell my friends about what I find to be the best shoe brand for toddlers and kids!
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Reviewed in the United States on September 10, 2025
★★★★★ 3
Summer Slides
Size: 1 Big Kid, Color: Lilac/Glitter
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Reviewed in the United States on May 31, 2024
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Size
Size: 3 Big Kid, Color: Black/Beige
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