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Do glucagon‑like peptide‑1 (GLP‑1) receptor agonists such as semaglutide, liraglutide, dulaglutide, and tirzepatide improve symptoms of postural orthostatic tachycardia syndrome (POTS) and mast‑cell activation syndrome ( MCAS)?
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Not all GLP-1s work the same way for MCAS. Most patients do better on Tirzepatide, the dual incretin with both GLP-1 and GIP receptor agonists. But some mast cells just respond better
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